Skip to main content
close

KingCounty.gov is an official government website. Here's how you knowexpand_moreexpand_less

account_balance

Official government websites use .gov

Website addresses ending in .gov belong to official government organizations in the United States.

lock

Secure .gov websites use HTTPS

A lock lock or https:// means you've safely connected to the .gov website. Only share sensitive information on official, secure websites.

King County Logo

December 3, 2025

Hepatitis B Vaccine Birth Dose for Newborns – Actions for Providers

➜ This health advisory is also available in PDF format (296 KB)

Public Health continues to recommend that all newborns receive the hepatitis B vaccine within 24 hours of delivery. Additionally, all children should complete the full 3 to 4 dose hepatitis B vaccine series by 18 months of age. Providing the birth dose and completing the series on time offers essential protection during a period of high vulnerability. Delaying vaccination risks missing a crucial window of potential exposure, putting infants at risk for lifelong disease. These recommendations align with the American Academy of Pediatrics (AAP) Recommended Child and Adolescent Immunization Schedule.

Current situation

  • The Advisory Committee on Immunization Practices (ACIP) is expected to vote on changes to the hepatitis B birth dose recommendation at its next meeting, December 4-5, 2025.
  • Hepatitis B birth dose remains critical for preventing perinatal transmission and has been tested extensively for safety and efficacy.  
  • This Health Advisory reinforces key evidence to support immunizing newborns against hepatitis B to prevent cases of perinatally-acquired hepatitis B infections.

Actions requested

  • Continue to administer hepatitis B vaccine to all newborns based on the below flowchart adapted from Elimination of Perinatal Hepatitis B: Providing the First Vaccine Dose Within 24 Hours of Birth, Am. Academy of Pediatrics
  • Ensure completion of the 3-4 dose hepatitis B vaccine series by 18 months of age regardless of the birth parents’ hepatitis B infection status.
  • For infants born to a parent who is hepatitis B-positive, perform perinatal post-vaccination serologic testing 1-2 months after vaccine series completion, but not before 9 months of age.

Hepatitis B vaccine for newborns flowchart

Background

  • Hepatitis B is a viral infection that attacks the liver and can cause both acute and chronic disease, including cirrhosis, liver failure, liver cancer, and death. 
  • Hepatitis B is transmitted through blood or body fluids, and perinatal exposure typically occurs during labor and delivery. 
  • Infants can also contract hepatitis B from caregivers, household contacts, and others with known or unknown hepatitis B infection, or from blood-contaminated surfaces and objects.
  • Hepatitis B infection is particularly devastating to infants.
    • Newborns infected with hepatitis B at birth and infants infected in the first year of life have a 90% chance of developing chronic hepatitis B which has no cure.
    • One in four people infected with hepatitis B virus during childhood die from the disease later in life.
  • The CDC and the AAP have recommended hepatitis B vaccination since 1991 for all newborns to protect them from this serious but preventable disease.
    • The birth dose recommendation is part of a safety net to protect infants born to someone who is infected with hepatitis B that has gone undiagnosed.
    • Since 1991, hepatitis B infections in children and teens have decreased by 99%.
  • Newborns respond well to a birth dose of the hepatitis B vaccine, and after completing the full 3-4 dose vaccine series, 98% of healthy infants achieve full immunity to the virus that lasts at least 30 years.
    • Timely vaccination is essential to reduce the risk of chronic hepatitis B and associated complications.
  • Studies have consistently shown the hepatitis B vaccine is safe and effective, and severe reactions are rare.

Resources

expand_less